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Nilotinib hcl monohydrate

Nilotinib hcl monohydrate 923288-90-8
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Chemical Information
Product name:Nilotinib hcl monohydrate Purity:98% min
CAS NO:923288-90-8 Solubility:DMSO: ≥ 33 mg/mL
Molecular Formula:C28H25ClF3N7O2 Package:Package according to customer requirements
Molecular Weight:584.0 Storage:Store at -20℃
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Nilotinib, also known as AMN-107, is an orally bioavailable aminopyrimidine-derivative Bcr-Abl tyrosine kinase inhibitor with antineoplastic activity. Designed to overcome imatinib resistance, nilotinib binds to and stabilizes the inactive conformation of the kinase domain of the Abl protein of the Bcr-Abl fusion protein, resulting in the inhibition of the Bcr-Abl-mediated proliferation of Philadelphia chromosome-positive (Ph+) chronic myeloid leukemia (CML) cells. This agent also inhibits the receptor tyrosine kinases platelet-derived growth factor receptor (PDGF-R) and c-kit, a receptor tyrosine kinase mutated and constitutively activated in most gastrointestinal stromal tumors (GISTs).

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