Cycloheximide (CHX) is the most common laboratory reagent used to inhibit protein synthesis. Cycloheximide has been shown to block the elongation phase of eukaryotic translation. Cycloheximide binds the ribosome and inhibits eEF2-mediated translocation. Surprisingly, Cycloheximide allows one complete translocation cycle to proceed before halting any further elongation. Cycloheximide has been speculated that Cycloheximide requires an E-site bound deacylated tRNA for activity.
Properties:
Appearance & Physical State: Off-white to light tan powder
Density: 1.136 g/cm3
Boiling Point: 491.8ºC at 760 mmHg
Melting Point: 107-114ºC
Flash Point: 251.2ºC
Refractive Index: 1.498
Water Solubility: 2.1 g/100 mL (2 ºC)
Related Prodcuts:
Moxifloxacin; Moxifloxacin HCL; Fasudil; Fasudil HCL; Pixantrone Maleate; Topotecan Hydrochloride; Irinotecan HCl Trihydrate; Irinotecan; Gemfibrozil; Oxaliplatin; Camptothecin; 10-Hydroxycamptothecin; Bendamustine hydrochloride