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Irinotecan HCl trihydrate

Irinotecan HCl trihydrate  136572-09-3
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Chemical Information
Product name:Irinotecan HCl trihydrate Purity:98% min
CAS NO:136572-09-3 Solubility:DMSO; H2O: 1.52 mg/mL
Molecular Formula:C33H45ClN4O9 Package:Packaging according to customer requirements
Molecular Weight:677.18 Storage:Store at -20℃
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Remarks
Irinotecan hydrochloride trihydrate is a topoisomerase I inhibitor. Irinotecan inhibits the growth of LoVo and HT-29 cells, with IC50s of 15.8 ± 5.1 and 5.17 ± 1.4 μM, respectively, and induces similar amounts of cleavable complexes in both in LoVo and HT-29 cells. Irinotecan suppresses the proliferation of human umbilical vein endothelial cells (HUVEC), with an IC50 of 1.3 μM.
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