KGA-2727 is a potent, selective, high-affinity inhibitor of sodium glucose cotransporter 1 (SGLT1) with Ki of 97.4 nM and 43.5 nM for human SGLT1 and rat SGLT1, respectively. The selectivity ratios (Ki for SGLT2/Ki for SGLT1) of KGA-2727 are 140 (human) and 390 (rat). KGA-2727 exhibits antidiabetic efficacy in rodent models.
Properties:
Boiling point: 839.6±65.0 °C(Predicted)
density: 1.308±0.06 g/cm3(Predicted)
pka: 12.65±0.70(Predicted)
SGLT Inhibitors Related Prodcuts:
Canagliflozin; Empagliflozin; Sotagliflozin; Ertugliflozin; Dapagliflozin