Timapiprant (OC000459)

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Chemical Information

Product name：Timapiprant (OC000459)	Purity：98% min
CAS NO：851723-84-7	Solubility：DMSO : 4 mg/mL (11.48 mM)
Molecular Formula：C₂₁H₁₇FN₂O₂	Package：Package according to customer requirements
Molecular Weight：348.370	Storage：Store at -20℃

Quality control

Remarks

Timapiprant, also known as OC000459, is a potent, selective and orally active CRTH2 antagonist. OC000459 reduces nasal and ocular symptoms in allergic subjects exposed to grass pollen, a randomised, placebo-controlled, double-blind trial. OC000459 inhibits mast cell-dependent activation of T helper 2 lymphocytes and eosinophils. OC000459 treatment inhibited LAR and post-allergen increase in sputum eosinophils. OC000459 appears to inhibit allergic inflammation in asthma.

Properties:

Density: 1.297 g/cm3

Boiling Point: 574.416ºC at 760 mmHg

Flash Point: 301.196ºC

GPR Inhibitors Related Prodcuts:

JMS-17-2; GSK137647A; CID 1375606; APD668

References

[1]. Singh D, Cadden P, Hunter M, Inhibition of the asthmatic allergen challenge response by the CRTH2 antagonist OC000459. Eur Respir J. 2013 Jan;41(1):46-52.

[2]. Horak F, Zieglmayer P, Zieglmayer R, The CRTH2 antagonist OC000459 reduces nasal and ocular symptoms in allergic subjects exposed to grass pollen, a randomised, placebo-controlled, double-blind trial. Allergy. 2012 Dec;67(12):1572-9.