KU-60019

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Chemical Information

Product name：KU-60019	Purity：98% min
CAS NO：925701-49-1	Solubility：DMSO : ≥ 30 mg/mL (54.78 mM)
Molecular Formula：C₃₀H₃₃N₃O₅S	Package：Package according to customer requirements
Molecular Weight：547.66512	Storage：Store at -20℃

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Remarks

KU-60019 is a potent and selective ATM inhibitor. KU-60019 is 10-fold more effective than KU-55933 at blocking radiation-induced phosphorylation of key ATM targets in human glioma cells. As expected, KU-60019 is a highly effective radiosensitizer of human glioma cells. KU-60019 inhibits the DNA damage response, reduces AKT phosphorylation and prosurvival signaling, inhibits migration and invasion, and effectively radiosensitizes human glioma cells.

ATM/ATR Inhibitors Related Products:

Dactolisib; KU-55933; Wortmannin; CP-466722; Elimusertib (BAY-1895344); AZ32; Mirin

References

[1]. Golding SE, et al. Improved ATM kinase inhibitor KU-60019 radiosensitizes glioma cells, compromises insulin, AKT and ERK prosurvival signaling, and inhibits migration and invasion. Mol Cancer Ther. 2009 Oct;8(10):2894-902.

[2]. McCabe N, et al. Mechanistic Rationale to Target PTEN-Deficient Tumor Cells with Inhibitors of the DNA Damage Response Kinase ATM. Cancer Res. 2015 Jun 1;75(11):2159-65.