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KU-60019 925701-49-1
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Chemical Information
Product name:KU-60019 Purity:98% min
CAS NO:925701-49-1 Solubility:DMSO : ≥ 30 mg/mL (54.78 mM)
Molecular Formula:C30H33N3O5S Package:Package according to customer requirements
Molecular Weight:547.66512 Storage:Store at -20℃
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KU-60019 is a potent and selective ATM inhibitor. KU-60019 is 10-fold more effective than KU-55933 at blocking radiation-induced phosphorylation of key ATM targets in human glioma cells. As expected, KU-60019 is a highly effective radiosensitizer of human glioma cells. KU-60019 inhibits the DNA damage response, reduces AKT phosphorylation and prosurvival signaling, inhibits migration and invasion, and effectively radiosensitizes human glioma cells.

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