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ARRY-380 analog

ARRY-380 analog 937265-83-3
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Chemical Information
Product name:ARRY-380 analog Purity:98% min
CAS NO:937265-83-3 Solubility:10 mM in DMSO
Molecular Formula:C29H27N7O4S Package:Package according to customer requirements
Molecular Weight:569.6340 Storage:Store at -20℃
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ARRY-380 analog is an analog of ARRY-380. ARRY-380 is also know as Tucatinib, also known as Irbinitinib, and ONT-380, is a n orally bioavailable inhibitor of the human epidermal growth factor receptor tyrosine kinase ErbB-2 (also called HER2) with potential antineoplastic activity. ErbB-2 inhibitor ARRY-380 selectively binds to and inhibits the phosphorylation of ErbB-2, which may prevent the activation of ErbB-2 signal transduction pathways, resulting in growth inhibition and death of ErbB-2-expressing tumor cells. ErbB-2 is overexpressed in a variety of cancers and plays an important role in cellular proliferation and differentiation.

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