ARRY-380 analog is an analog of ARRY-380. ARRY-380 is also know as Tucatinib, also known as Irbinitinib, and ONT-380, is a n orally bioavailable inhibitor of the human epidermal growth factor receptor tyrosine kinase ErbB-2 (also called HER2) with potential antineoplastic activity. ErbB-2 inhibitor ARRY-380 selectively binds to and inhibits the phosphorylation of ErbB-2, which may prevent the activation of ErbB-2 signal transduction pathways, resulting in growth inhibition and death of ErbB-2-expressing tumor cells. ErbB-2 is overexpressed in a variety of cancers and plays an important role in cellular proliferation and differentiation.
EGFR Inhibitors Related Products:
PD153035; Nazartinib; AZD3759; Erlotinib; CL-387785; AZ-5104; MTX-211; Osimertinib; Osimertinib mesylate; Olmutinib; Afatinib Dimaleate; Rociletinib; EGFR-IN-7