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Afatinib dimaleate

Afatinib dimaleate  850140-73-7
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Chemical Information
Product name:Afatinib dimaleate Purity:98% min
CAS NO:850140-73-7 Solubility:DMSO: ≥ 35 mg/mL
Molecular Formula:C32H33ClFN5O11 Package:Packaging according to customer requirements
Molecular Weight:718.09 Storage:Store at -20℃
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Remarks
Afatinib dimaleate is an orally bioavailable dual receptor tyrosine kinase (RTK) inhibitor with potential antineoplastic activity. EGFR/HER2 tyrosine kinase inhibitor BIBW 2992 irreversibly binds to and inhibits human epidermal growth factor receptors 1 and 2 (EGFR-1; HER2), which may result in the inhibition of tumor growth and angiogenesis. EGFR/HER2 are RTKs that belong to the EGFR superfamily; both play major roles in tumor cell proliferation and tumor vascularization and are overexpressed in many cancer cell types. Afatinib is approved in much of the world (including the United States, Canada, the United Kingdom and Australia) for the treatment of metastatic non-small cell lung carcinoma (NSCLC), developed by Boehringer Ingelheim. It acts as an angiokinase inhibitor.
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