SU6656

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Chemical Information

Product name：SU6656	Purity：98% min
CAS NO：330161-87-0	Solubility：DMSO : 18.5 mg/mL (49.80 mM)
Molecular Formula：C₁₉H₂₁N₃O₃S	Package：Package according to customer requirements
Molecular Weight：371.453	Storage：Store at -20℃

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Remarks

SU6656 is a potent and selective dual inhibitor of Src family kinases and Aurora kinase. SU6656 modulates CTGF (connective tissue growth factor) expression in an ERK-dependent manner. SU6656 induces caspase-independent cell death in FRO anaplastic thyroid carcinoma cells and therapeutic synergy in human synovial sarcoma growth, invasion and angiogenesis in vivo.

Properties:
Density: 1.378g/cm3
Refractive Index: 1.656

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References

[1]. Blake RA, et al. SU6656, a selective src family kinase inhibitor, used to probe growth factor signaling. Mol Cell Biol. 2000 Dec;20(23):9018-27.

[2]. Veracini L, et al. Elevated Src family kinase activity stabilizes E-cadherin-based junctions and collective movement of head and neck squamous cell carcinomas. Oncotarget. 2014 Dec 26.