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A-966492

A-966492 934162-61-5
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Chemical Information
Product name:A-966492 Purity:98% min
CAS NO:934162-61-5 Solubility:DMSO : ≥ 100 mg/mL (308.31 mM)
Molecular Formula:C18H17FN4O Package:Package according to customer requirements
Molecular Weight:324.352 Storage:Store at -20℃
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Remarks

A-966492 is a potent PARP inhibitor, which displayed excellent potency against the PARP-1 enzyme with a K(i) of 1 nM and an EC(50) of 1 nM in a whole cell assay. In addition, A-966492 is orally bioavailable across multiple species, crosses the blood-brain barrier, and appears to distribute into tumor tissue. It also demonstrated good in vivo efficacy in a B16F10 subcutaneous murine melanoma model in combination with temozolomide and in an MX-1 breast cancer xenograft model both as a single agent and in combination with carboplatin.

 

 

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Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.
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