PP1 is a potent and selective Src family protein tyrosine kinase inhibitor. PP1 effectively blocks TGF-beta1-induced cell migration and invasion in both established and primary carcinoma cells. PP1 blocks TGF-beta1-mediated cellular responses by direct and differential inhibition of type I and type II TGF-beta receptors. PP1 was also found to potentiate tumor-suppressive effect of connexin 32 gene in renal cancer cells.
Appearance & Physical State: Off-white to grey solid
Boiling Point: 478.8ºC at 760 mmHg
Melting Point: 205-207ºC
Flash Point: 243.4ºC
Refractive Index: 1.652
Vapor Pressure: 2.49E-09mmHg at 25°C
Afatinib dimaleate; Neratinib; Bosutinib; Bosutinib Intermediates; Bosutinib Monohydrate; Saracatinib; Dasatinib; NVP-BHG712; PP2; A-966492; G007-LK; SU6656; Tirbanibulin; TPX-0005; Afatinib