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Product :

PP2 AGL 1879

PP2 AGL 1879 172889-27-9
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Chemical Information
Product name:PP2 AGL 1879 Purity:98% min
CAS NO:172889-27-9 Solubility:DMSO : 50 mg/mL (165.69 mM); H2O : < 0.1 mg/mL
Molecular Formula:C15H16ClN5 Package:Package according to customer requirements
Molecular Weight:301.774 Storage:Store at -20℃
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Remarks

PP2, also known as AG 1879, is a substance that has frequently been used in cancer research as a "selective" inhibitor for Src-family kinases. It strongly inhibits the kinases Lck (IC50=4 nM), Fyn (5 nM) and Hck (5 nM), shows weaker inhibition of EGFR (480 nM) and practically no inhibition of ZAP-70 (100 µM) and JAK2 (50 µM). Despite its extensive use as a Src-selective inhibitor, recent research has shown that PP2 is non-selective and inhibits many other kinases with similar affinities.

 

Properties:

Appearance & Physical State: White solid

Density: 1.35 g/cm3

Boiling Point: 493.5ºC at 760 mmHg

Melting Point: 214-216ºC

Flash Point: 252.3ºC

Refractive Index: 1.676

Vapor Pressure: 6.98E-10mmHg at 25°C

 

 

 

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Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.
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