PP2, also known as AG 1879, is a substance that has frequently been used in cancer research as a "selective" inhibitor for Src-family kinases. It strongly inhibits the kinases Lck (IC50=4 nM), Fyn (5 nM) and Hck (5 nM), shows weaker inhibition of EGFR (480 nM) and practically no inhibition of ZAP-70 (100 µM) and JAK2 (50 µM). Despite its extensive use as a Src-selective inhibitor, recent research has shown that PP2 is non-selective and inhibits many other kinases with similar affinities.
Properties:
Appearance & Physical State: White solid
Density: 1.35 g/cm3
Boiling Point: 493.5ºC at 760 mmHg
Melting Point: 214-216ºC
Flash Point: 252.3ºC
Refractive Index: 1.676
Vapor Pressure: 6.98E-10mmHg at 25°C
Related Products:
Afatinib dimaleate; Neratinib; Bosutinib; Bosutinib Intermediates; Bosutinib Monohydrate; Saracatinib; Dasatinib; NVP-BHG712; PP1; A-966492; G007-LK; SU6656; Tirbanibulin; TPX-0005; Afatinib