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Neratinib HKI-272

Neratinib HKI-272  698387-09-6
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Chemical Information
Product name:Neratinib HKI-272 Purity:98% min
CAS NO:698387-09-6 Solubility:DMSO: 6.4 mg/mL (Need ultrasonic)
Molecular Formula:C30H29ClN6O3 Package:Packaging according to customer requirements
Molecular Weight:557.04 Storage:Store at -20℃
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Remarks
Neratinib, also known as HKI-272 or PB272, is an orally available, 6,7-disubstituted-4-anilinoquinoline-3-carbonitrile irreversible inhibitor of the HER-2 receptor tyrosine kinase with potential antineoplastic activity. Neratinib binds to the HER-2 receptor irreversibly, thereby reducing autophosphorylation in cells, apparently by targeting a cysteine residue in the ATP-binding pocket of the receptor. Treatment of cells with this agent results in inhibition of downstream signal transduction events and cell cycle regulatory pathways; arrest at the G1-S (Gap 1/DNA synthesis)-phase transition of the cell division cycle; and ultimately decreased cellular proliferation. Neratinib also inhibits the epidermal growth factor receptor (EGFR) kinase and the proliferation of EGFR-dependent cells.
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