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KU-0063794

KU-0063794 938440-64-3
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Chemical Information
Product name:KU-0063794 Purity:98% min
CAS NO:938440-64-3 Solubility:10 mM in DMSO
Molecular Formula:C25H31N5O4 Package:Package according to customer requirements
Molecular Weight:465.545 Storage:Store at -20℃
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Remarks
KU-0063794 is a potent and selective mTOT inhibitor, which inhibits both mTORC1 and mTORC2 with an IC50 of approximately 10 nM, but does not suppress the activity of 76 other protein kinases or seven lipid kinases, including Class 1 PI3Ks (phosphoinositide 3-kinases) at 1000-fold higher concentrations. KU-0063794 is cell permeant, suppresses activation and hydrophobic motif phosphorylation of Akt, S6K and SGK, but not RSK (ribosomal S6 kinase), an AGC kinase not regulated by mTOR. Ku-0063794 also inhibited phosphorylation of the T-loop Thr308 residue of Akt phosphorylated by PDK1 (3-phosphoinositide-dependent protein kinase-1). Ku-0063794 will be useful in delineating the physiological roles of mTOR and may have utility in treatment of cancers in which this pathway is inappropriately activated.
Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.
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