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Glibenclamide Glyburide

Glibenclamide Glyburide 10238-21-8
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Chemical Information
Product name:Glibenclamide Glyburide Purity:99% min
CAS NO:10238-21-8 Solubility:DMSO : ≥ 60 mg/mL (121.46 mM)
Molecular Formula:C23H28ClN3O5S Package:Package according to customer requirements
Molecular Weight:494.004 Storage:Store at 2-8ºC
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Remarks

Glyburide is an antidiabetic sulfonylurea derivative with actions similar to those of chlorpropamide that can potentially be used to decrease cerebral edema. Upon administration, glyburide binds to and blocks the sulfonylurea receptor type 1 (SUR1) subunit of the ATP-sensitive inwardly-rectifying potassium (K(ATP)) channels on the membranes of pancreatic beta cells. This prevents the inward current flow of positively charged potassium (K+) ions into the cell, and induces a calcium ion (Ca2+) influx through voltage-sensitive calcium channels, which triggers exocytosis of insulin-containing granules.

 

Properties:
Appearance & Physical State: white or almost white crystalline podwer
Density: 1.36 g/cm3
Melting Point: 173-175ºC
Refractive Index: 1.628
 

 

 

Potassium Channel Inhibitors Related Prodcuts:

Glimepiride; Vonoprazan Fumarate; Gliclazide; Almitrine dimesylate; JNJ303; Dofetilide; Dronedarone HCl; Mitiglinide Calcium

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.
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