Gliclazide

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Chemical Information

Product name：Gliclazide	Purity：98% min
CAS NO：21187-98-4	Solubility：DMSO : ≥ 100 mg/mL (309.21 mM)
Molecular Formula：C₁₅H₂₁N₃O₃S	Package：Package according to customer requirements.
Molecular Weight：323.411	Storage：Store at -20℃

Quality control

Remarks

Gliclazide is an oral hypoglycemic (anti-diabetic drug) and is classified as a sulfonylurea. Its classification has been ambiguous, as literature uses it as both a first-generation and second-generation sulfonylurea. Gliclazide was shown to protect human pancreatic beta-cells from hyperglycemia-induced apoptosis. It was also shown to have an antiatherogenic effect (preventing accumulation of fat in arteries) in type 2 diabetes.

Properties
Appearance & Physical State: white powder
Density: 1.35 g/cm3
Melting Point: 163-169ºC
Refractive Index: 1.623

Potassium Channel Inhibitors Related Prodcuts:

Glimepiride; Vonoprazan Fumarate; Almitrine dimesylate; JNJ303; Dofetilide; Dronedarone HCl; Mitiglinide Calcium ; Glyburide; ML213

References

[1]. Shimoyama, T., et al., Gliclazide protects 3T3L1 adipocytes against insulin resistance induced by hydrogen peroxide with restoration of GLUT4 translocation. Metabolism, 2006. 55(6): p. 722-30.

[2]. Lawrence, C.L., et al., Gliclazide produces high-affinity block of KATP channels in mouse isolated pancreatic beta cells but not rat heart or arterial smooth muscle cells. Diabetologia, 2001. 44(8): p. 1019-25.