ML213 (CID-3111211)

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Chemical Information

Product name：ML213 (CID-3111211)	Purity：98% min
CAS NO：489402-47-3	Solubility：DMSO : 30 mg/mL (116.56 mM)
Molecular Formula：C₁₇H₂₃NO	Package：Package according to customer requirements
Molecular Weight：342.455	Storage：Store at -20℃

Quality control

Remarks

ML213, also known as CID-3111211, is a selective KV7.2 (KCNQ2) and KV7.4 (KCNQ4) channel opener (EC50 values are 230 and 510 nM for KV7.2 and KV7.4 respectively). ML213 displays > 80-fold selectivity against KV7.1, KV7.3 and KV7.5 in a thallium-based fluorescence assay.

Chemical Name:

N-(2,4,6-trimethylphenyl)bicyclo[2.2.1]heptane-3-carboxamide

Potassium Channel Inhibitors Related Prodcuts:

Glimepiride; Vonoprazan Fumarate; Gliclazide; Almitrine dimesylate; JNJ303; Dronedarone HCl; Mitiglinide Calcium ; Glyburide; Dofetilide

References

[1]. Brueggemann LI, et al. Differential activation of vascular smooth muscle Kv7.4, Kv7.5, and Kv7.4/7.5 channels by ML213 and ICA-069673. Mol Pharmacol. 2014 Sep;86(3):330-41.

[2]. Jepps TA, et al. Vasorelaxant effects of novel Kv 7.4 channel enhancers ML213 and NS15370. Br J Pharmacol. 2014 Oct;171(19):4413-24.