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Product :

BS-181

BS-181 1092443-52-1
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Chemical Information
Product name:BS-181 Purity:98% min
CAS NO:1092443-52-1 Solubility:DMSO : ≥ 50 mg/mL (131.40 mM)
Molecular Formula:C22H33ClN6 Package:Package according to customer requirements
Molecular Weight:416.991 Storage:Store at -20℃
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Remarks

BS-181 is a highly selective CDK inhibitor for CDK7 with an IC(50) of 21 nmol/L. Testing of other CDKs as well as another 69 kinases showed that BS-181 only inhibited CDK2 at concentrations lower than 1 micromol/L, with CDK2 being inhibited 35-fold less potently (IC(50) 880 nmol/L) than CDK7. In MCF-7 cells, BS-181 inhibited the phosphorylation of CDK7 substrates, promoted cell cycle arrest and apoptosis to inhibit the growth of cancer cell lines, and showed antitumor effects in vivo.

 

 

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