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Flavopiridol Alvocidib

Flavopiridol Alvocidib 146426-40-6
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Chemical Information
Product name:Flavopiridol Alvocidib Purity:98% min
CAS NO:146426-40-6 Solubility:10 mM in DMSO
Molecular Formula:C21H20ClNO5 Package:Package according to customer requirements
Molecular Weight:401.840 Storage:Store at -20℃
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Remarks
Flavopiridol (2 μM) robustly induces a distinct pattern of ER stress in CLL cells that contributes to cell death through IRE1-mediated activation of ASK1 and possibly downstream caspases. Flavopiridol results in potent upregulation of a number of PRGs in treatments lasting 4-24 h. Flavopiridol has and immediate and long-term effect on the expression of several PRGs. In serum starved cells re-stimulated with serum, flavopiridol also inhibits the expression of these genes, but subsequently, JUNB, GADD45B and EGR1 are upregulated in the presence of flavopiridol.
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