Alvocidib Flavopiridol HCL

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Chemical Information

Product name：Alvocidib Flavopiridol HCL	Purity：98% min
CAS NO：131740-09-5	Solubility：H2O : ≥ 20 mg/mL (45.63 mM)
Molecular Formula：C₂₁H₂₁Cl₂NO₅	Package：Package according to customer requirements
Molecular Weight：438.301	Storage：Store at -20℃

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Remarks

Flavopiridol HCl (L86-8275, NSC 649890, Alvocidib, HMR-1275, DSP-2033) competes with ATP to inhibit CDKs including CDK1, CDK2, CDK4 and CDK6 with IC50 of ~ 40 nM in cell-free assays. It is 7.5-fold more selective for CDK1/2/4/6 than CDK7. Flavopiridol is initially found to inhibit EGFR and PKA. Flavopiridol HCl induces autophagy and ER stress. Flavopiridol HCl blocks HIV-1 replication. Phase 1/2.

Related Products:

Flavopiridol; THZ1; BMS-863233 HCl; Dinaciclib; AZD5438; Seliciclib; Palbociclib Isethionate; PHA-793887; RO-3306; Abemaciclib mesylate; Abemaciclib; JNJ-7706621

References

[1]. Mahoney E, et al. ER stress and autophagy: new discoveries in the mechanism of action and drug resistance of the cyclin-dependent kinase inhibitor flavopiridol.Blood. 2012 Aug 9;120(6):1262-1273.

[2]. Keskin H, et al. Complex effects of flavopiridol on the expression of primary response genes. Cell Div. 2012 Mar 29;7:11.

[3]. Kim KS, et al.Thio- and oxoflavopiridols, cyclin-dependent kinase 1-selective inhibitors: synthesis and biological effects. J Med Chem. 2000 Nov 2;43(22):4126-34.