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LY2835219 abemaciclib mesylate

LY2835219 abemaciclib mesylate 1231930-82-7
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Chemical Information
Product name:LY2835219 abemaciclib mesylate Purity:98% min
CAS NO:1231930-82-7 Solubility:DMSO : ≥ 25 mg/mL (41.48 mM)
Molecular Formula:C28H36F2N8O3S Package:Package according to customer requirements
Molecular Weight:602.699 Storage:Store at -20℃
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Remarks

Abemaciclib, also known as LY2835219, is orally available cyclin-dependent kinase (CDK) inhibitor that targets the CDK4 (cyclin D1) and CDK6 (cyclin D3) cell cycle pathway, with potential antineoplastic activity. LY2835219 inhibits CDK4 and CDK6 with low nanomolar potency. LY2835219 specifically inhibits CDK4 and 6, thereby inhibiting retinoblastoma (Rb) protein phosphorylation in early G1. Inhibition of Rb phosphorylation prevents CDK-mediated G1-S phase transition, thereby arresting the cell cycle in the G1 phase, suppressing DNA synthesis and inhibiting cancer cell growth.

 

 

 

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Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.
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