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SCH727965 Dinaciclib

SCH727965 Dinaciclib 779353-01-4
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Chemical Information
Product name:SCH727965 Dinaciclib Purity:98% min
CAS NO:779353-01-4 Solubility:DMSO : ≥ 56 mg/mL (141.24 mM)
Molecular Formula:C21H28N6O2 Package:Package according to customer requirements
Molecular Weight:396.486 Storage:Store at -20℃
Quality control
Dinaciclib, also known as SCH727965, is a potent CDK inhibitor with potential antineoplastic activity. Dinaciclib selectively inhibits cyclin dependent kinases CDK1, CDK2, CDK5, and CDK9 activity in vitro with IC(50) values of 1, 1, 3, and 4 nmol/L, respectively. Compared with flavopiridol, Dinaciclib exhibits superior activity with an improved therapeutic index. Dinaciclib induced regression of established solid tumors in a range of mouse models following intermittent scheduling of doses below the maximally tolerated level.
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