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Product :

JNJ-7706621

JNJ-7706621 443797-96-4
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Chemical Information
Product name:JNJ-7706621 Purity:98% min
CAS NO:443797-96-4 Solubility:10 mM in DMSO
Molecular Formula:C15H12F2N6O3S Package:Package according to customer requirements
Molecular Weight:394.356 Storage:Store at -20℃
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Remarks

 JNJ-7706621 is a novel cell cycle inhibitor that showed potent inhibition of several cyclin-dependent kinases (CDK) and Aurora kinases and selectively blocked proliferation of tumor cells of various origins but was about 10-fold less effective at inhibiting normal human cell growth in vitro. In human cancer cells, treatment with JNJ-7706621 inhibited cell growth independent of p53, retinoblastoma, or P-glycoprotein status; activated apoptosis; and reduced colony formation. At low concentrations, JNJ-7706621 slowed the growth of cells and at higher concentrations induced cytotoxicity.

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