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Product :

PHA-793887

PHA-793887 718630-59-2
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Chemical Information
Product name:PHA-793887 Purity:98% min
CAS NO:718630-59-2 Solubility:DMSO : ≥ 50 mg/mL (138.32 mM)
Molecular Formula:C19H31N5O2 Package:Package according to customer requirements
Molecular Weight:361.482 Storage:Store at -20℃
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COA
Remarks

PHA-793887 is an inhibitor of multiple cyclin dependent kinases (CDK) with activity against CDK2, CDK1 and CDK4. PHA-793887 was cytotoxic for leukemic cell lines in vitro, with IC(50) ranging from 0.3 to 7 microM. In colony assays PHA-793887 showed very high activity against leukemia cell lines, with an IC(50) <0.1 microM indicating that it has efficient and prolonged antiproliferative activity. PHA-793887 induced cell-cycle arrest, inhibited Rb and nucleophosmin phosphorylation. PHA-793887 has promising therapeutic activity against acute leukemias in vitro and in vivo.

 

 

 

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