RO-3306

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Chemical Information

Product name：RO-3306	Purity：98% min
CAS NO：872573-93-8	Solubility：DMSO : ≥ 47 mg/mL (133.73 mM)
Molecular Formula：C₁₈H₁₃N₃OS₂	Package：Package according to customer requirements
Molecular Weight：351.445	Storage：Store at -20℃

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Remarks

RO-3306 is a CDK1 inhibitor with potential anticancer activity. Treatment of growing AML cells with RO-3306 induced G2/M-phase cell cycle arrest and apoptosis in a dose- and time-dependent manner. RO-3306 downregulated expression of the antiapoptotic proteins Bcl-2 and survivin and blocked p53-mediated induction of p21 and MDM2. RO-3306 actively enhances downstream p53 signaling to promote apoptosis.

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Flavopiridol HCL; Flavopiridol; THZ1; BMS-863233 HCl; Dinaciclib; AZD5438; Seliciclib; Palbociclib Isethionate; PHA-793887; Abemaciclib mesylate; Abemaciclib; JNJ-7706621

References

[1]. Vassilev LT, et al. Selective small-molecule inhibitor reveals critical mitotic functions of human CDK1. Proc Natl Acad Sci U S A. 2006 Jul 11;103(28):10660-5.

[2]. Kojima K, et al. Cyclin-dependent kinase 1 inhibitor RO-3306 enhances p53-mediated Bax activation and mitochondrial apoptosis in AML. Cancer Sci. 2009 Jun;100(6):1128-36.