NSC664704 Kenpaullone

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Chemical Information

Product name：NSC664704 Kenpaullone	Purity：98% min
CAS NO：142273-20-9	Solubility：DMSO : ≥ 35 mg/mL (106.97 mM)
Molecular Formula：C₁₆H₁₁BrN₂O	Package：Package according to customer requirements
Molecular Weight：327.175	Storage：Store at -20℃

Quality control

COA

Remarks

Kenpaullone is a potent inhibitor of CDK1/cyclin B (IC50 = 400 nM), CDK2/cyclin A (IC50 = 680 nM), CDK2/cyclin E (IC50 = 7.5 uM) and CDK5/p25 (IC50 = 850 nM). Kenpaullone inhibits CDK2/cyclin A, CDK2/cyclin E and CDK5/cyclin/p35 (IC50 values are 0.68, 7.5 and 0.85 μM respectively).

Related Products:

BMS-265246; LDC000067; Ribociclib; SU9516; Purvalanol A; Alvocidib; AZD-5597; ON123300; BS-181; JSH-150; Riviciclib

References

[1]. Zaharevitz DW, et al. Discovery and initial characterization of the paullones, a novel class of small-molecule inhibitors of cyclin-dependent kinases. Cancer Res. 1999 Jun 1;59(11):2566-9.

[2]. Lyssiotis CA, et al. Reprogramming of murine fibroblasts to induced pluripotent stem cells with chemical complementation of Klf4. Proc Natl Acad Sci U S A. 2009 Jun 2;106(22):8912-7.