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Product :

Epacadostat

Epacadostat 1204669-58-8
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Chemical Information
Product name:Epacadostat Purity:98% min
CAS NO:1204669-58-8 Solubility:DMSO : ≥ 31 mg/mL (70.74 mM)
Molecular Formula:C11H13BrFN7O4S Package:Package according to customer requirements
Molecular Weight:438.233 Storage:Store at -20℃
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Remarks

Epacadostat, also known as INCB024360 or INCB24360, is an orally available hydroxyamidine and inhibitor of indoleamine 2,3-dioxygenase (IDO1), with potential immunomodulating and antineoplastic activities. INCB024360 targets and binds to IDO1, an enzyme responsible for the oxidation of tryptophan into kynurenine. By inhibiting IDO1 and decreasing kynurenine in tumor cells, INCB024360 increases and restores the proliferation and activation of various immune cells, including dendritic cells (DCs), NK cells, and T-lymphocytes, as well as interferon (IFN) production, and a reduction in tumor-associated regulatory T cells (Tregs).

 

 

 

IDO/TDO Inhibitors Related Prodcuts:

NLG-919 analogue; Linrodostat; Indoximod; PF-06840003

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.
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