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PF-06840003 EOS200271

PF-06840003 EOS200271 198474-05-4
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Chemical Information
Product name:PF-06840003 EOS200271 Purity:98% min
CAS NO:198474-05-4 Solubility:DMSO : ≥ 28 mg/mL (120.58 mM)
Molecular Formula:C12H9FN2O2 Package:Package according to customer requirements
Molecular Weight:232.210 Storage:Store at -20℃
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Remarks
PF-06840003, also known as EOS200271, is potent IDO-1 inhibitor (IC50 0.15 μM). PF-0684000 has moderate hIDO1 enzyme inhibition (IC50 0.41 μM). It is a highly efficient compound (LE 0.53, LipE 5.1), driven by its tight packing within the enzyme, as well as the high density of hydrogen bonds it forms with hIDO-1 despite its small size. PF-0684000 shows good potency in an IDO-1 human whole blood assay and also shows a very favorable ADME profile leading to favorable predicted human pharmacokinetic properties, including a predicted half-life of 16−19 h.
Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.
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