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GDC-0919 NLG-919 analogue

GDC-0919 NLG-919 analogue 1402836-58-1
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Chemical Information
Product name:GDC-0919 NLG-919 analogue Purity:98% min
CAS NO:1402836-58-1 Solubility:DMSO : 15 mg/mL (53.12 mM)
Molecular Formula:C18H22N2O Package:Package according to customer requirements.
Molecular Weight:282.38 Storage:Store at -20℃
Quality control
COA
Remarks

GDC-0919, also known as NLG919 and RG6078, is an orally available inhibitor of indoleamine 2,3-dioxygenase 1 (IDO1), with potential immunomodulating and antineoplastic activities. Upon administration, NLG919 targets and binds to IDO1, a cytosolic enzyme responsible for the oxidation of the essential amino acid tryptophan into kynurenine. By inhibiting IDO1 and decreasing kynurenine in tumor cells, this agent increases tryptophan levels, restores the proliferation and activation of various immune cells, including dendritic cells (DCs), natural killer (NK) cells, T-lymphocytes, and causes a reduction in tumor-associated regulatory T-cells (Tregs). Activation of the immune system, which is suppressed in many cancers, may induce a cytotoxic T-lymphocyte (CTL) response against the IDO1-expressing tumor cells.

 

 

 

IDO/TDO Inhibitors Related Prodcuts:

Linrodostat; Epacadostat; Indoximod; PF-06840003

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.
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