Alosetron hydrochloride

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Chemical Information

Product name：Alosetron hydrochloride	Purity：99% min
CAS NO：122852-69-1	Solubility：H2O : 33.33 mg/mL (100.75 mM; Need ultrasonic)
Molecular Formula：C₁₇H₁₉ClN₄O	Package：Package according to customer requirements.
Molecular Weight：330.812	Storage：Store at -20℃

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Remarks

Alosetron Hydrochloride (GR 68755C) is a potent and highly selective serotonin 5-HT3 receptor antagonist. Alosetron Hydrochloride is used for the research of irritable bowel syndrome (IBS). Alosetron blocks the fast 5HT3-mediated depolarisation of guinea-pig myenteric and submucosal neurons, with IC50 at ~55 nM. Alosetron Hydrochloride attenuates the visceral nociceptive effect of rectal distension in conscious or anaesthetised dogs. Anti-inflammatory effects.

Properties:

Appearance & Physical State: Off-white powder

Density: 1.34g/cm3

Boiling Point: 648.1ºC at 760 mmHg

Melting Point: 288-291ºC

Flash Point: 345.8ºC

Vapor Pressure: 1.1E-16mmHg at 25°C

5-HT Receptor Inhibitors Related Products:

Iloperidone; Olanzapine; Clozapine; Agomelatine; Duloxetine hydrochloride; Duloxetine; Palonosetron hydrochloride; Lurasidone; Lurasidone hydrochloride; Ramosetron Hydrochloride; Atomoxetine hcl

References

[1]. Targeting the 5-HT3 receptor in the treatment of irritable bowel syndrome By Spiller, Robin C. From Current Opinion in Pharmacology (2011), 11(1), 68-74.

[2]. Lucak SL. Optimizing outcomes with alosetron hydrochloride in severe diarrhea-predominant irritable bowel syndrome. Therap Adv Gastroenterol. 2010 May;3(3):165-72.