Clozapine is an atypical antipsychotic drug because it binds to serotonin as well as dopamine receptors. Clozapine is a partial agonist at the 5-HT1A subunit of the serotonin receptor, putatively improving depression, anxiety, and the negative cognitive symptoms associated with schizophrenia. A direct interaction of clozapine with the GABAB receptor has also been shown. GABAB receptor-deficient mice exhibit increased extracellular dopamine levels and altered locomotor behaviour equivalent to that in schizophrenia animal models.
Properties:
Appearance & Physical State: a yellow, crystalline powder, very slightly soluble in water
Density: 1.31 g/cm3
Boiling Point: 477.8ºC at 760 mmHg
Melting Point: 182-185ºC
Flash Point: 242.8ºC
Refractive Index: 1.681
Stability: Stable at normal temperatures and pressures.
5-HT Receptor Inhibitors Related Products:
Iloperidone; Olanzapine; Agomelatine; Duloxetine hydrochloride; Duloxetine; Alosetron hydrochloride; Palonosetron hydrochloride; Lurasidone; Lurasidone hydrochloride; Ramosetron Hydrochloride; Atomoxetine hcl