LY231514 pemetrexed

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Chemical Information

Product name：LY231514 pemetrexed	Purity：98% min
CAS NO：137281-23-3	Solubility：DMSO : ≥ 100 mg/mL (233.97 mM)
Molecular Formula：C₂₀H₂₁N₅O₆	Package：Package according to customer requirements
Molecular Weight：427.411	Storage：Store at -20℃

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Remarks

Pemetrexed is a novel antifolate, the K_i values of the pentaglutamate of LY231514 are 1.3, 7.2, and 65 nM for inhibits thymidylate synthase (TS), dihydrofolate reductase (DHFR), and glycinamide ribonucleotide formyltransferase (GARFT), respectively.

DHFR Inhibitors Related Products:

Pemetrexed disodium; Pemetrexed disodium heptahydrate; Amethopterin Methotrexate

References

[1]. Shih C, et al. LY231514, a pyrrolo[2,3-d]pyrimidine-based antifolate that inhibits multiple folate-requiring enzymes. Cancer Res. 1997 Mar 15;57(6):1116-23.

[2]. Anraku M, et al. Synergistic antitumor effects of regulatory T cell blockade combined with pemetrexed in murine malignantmesothelioma. J Immunol. 2010 Jul 15;185(2):956-66.