Pemtrexed disodium

Size	Price	Stock	Quantity
Get Quotation Now Add to Cart Bulk Inquiry

Shipping and handling fee USD40, Free delivery is qualified when the total value of your order exceeds USD500.If the item is temporarily out of stock. Please email to order@pharm-intermediates.com,we will inform you when we have it in stock.

Chemical Information

Product name：Pemtrexed disodium	Purity：98% min
CAS NO：150399-23-8	Solubility：H2O : ≥ 100 mg/mL (212.15 mM)
Molecular Formula：C₂₀H₁₉N₅Na₂O₆	Package：Package according to customer requirements.
Molecular Weight：471.374	Storage：Store at -20℃

Quality control

Remarks

Pemtrexed disodium is the disodium salt of a synthetic pyrimidine-based antifolate. Pemetrexed binds to and inhibits the enzyme thymidylate synthase (TS) which catalyses the methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP), an essential precursor in DNA synthesis.

DHFR Inhibitors Related Products:

Pemetrexed disodium heptahydrate; Amethopterin Methotrexate; Pemetrexed

References

[1]. Shih C, et al. LY231514, a pyrrolo[2,3-d]pyrimidine-based antifolate that inhibits multiple folate-requiring enzymes. Cancer Res. 1997 Mar 15;57(6):1116-23.

[2]. Anraku M, et al. Synergistic antitumor effects of regulatory T cell blockade combined with pemetrexed in murine malignantmesothelioma. J Immunol. 2010 Jul 15;185(2):956-66.