Pemetrexed disodium heptahydrate

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Chemical Information

Product name：Pemetrexed disodium heptahydrate	Purity：98% min
CAS NO：357166-29-1	Solubility：soluble in water at 100 mg/mL
Molecular Formula：C₂₀H₃₃N₅Na₂O₁₃	Package：Package according to customer requirements.
Molecular Weight：597.481	Storage：Store at -20℃

Quality control

COA

Remarks

Pemtrexed disodium is the disodium salt of a synthetic pyrimidine-based antifolate. Pemetrexed binds to and inhibits the enzyme thymidylate synthase (TS) which catalyses the methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP), an essential precursor in DNA synthesis.

DHFR Inhibitors Related Products:

Pemetrexed disodium; Amethopterin Methotrexate; Pemetrexed

References

1: Liu Y, Yin TJ, Zhou R, Zhou S, Fan L, Zhang RG. Expression of thymidylate synthase predicts clinical outcomes of pemetrexed-containing chemotherapy for non-small-cell lung cancer: a systemic review and meta-analysis. Cancer Chemother Pharmacol. 2013 Nov;72(5):1125-32. doi: 10.1007/s00280-013-2299-2. Epub 2013 Sep 26. Review. PubMed PMID: 24067998.

2: Boons CC, VAN Tulder MW, Burgers JA, Beckeringh JJ, Wagner C, Hugtenburg JG. The value of pemetrexed for the treatment of malignant pleural mesothelioma: a comprehensive review. Anticancer Res. 2013 Sep;33(9):3553-61. Review. PubMed PMID: 24023280.