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PIK-III 1383716-40-2
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Chemical Information
Product name:PIK-III Purity:98% min
CAS NO:1383716-40-2 Solubility:DMSO : ≥ 31 mg/mL (97.07 mM)
Molecular Formula:C17H17N7 Package:Package according to customer requirements
Molecular Weight:319.364 Storage:Store at -20℃
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PIK-III, also known as VPS34-IN2, is a VPS34 inhibitor which blocks autophagy and uncovers a role for NCOA4 in ferritin degradation and iron homeostasis in vivo. PIK-III binds a unique hydrophobic pocket not present in related kinases such as PI(3)Kα. PIK-III acutely inhibits autophagy and de novo lipidation of LC3, and leads to the stabilization of autophagy substrates. 



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PKI-402; Voxtalisib; Pilaralisib; PI-3065; VS-5584; PIK-294; AZD6482; GSK1059615; AZD8186; CUDC-907; AZD8835; AMG319; Buparlisib hydrochloride; Umbralisib; VPS34-IN1; VPS34 inhibitor 1; Wortmannin

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