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Maytansinoid DM1 Mertansine

Maytansinoid DM1 Mertansine 139504-50-0
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Chemical Information
Product name:Maytansinoid DM1 Mertansine Purity:98% min
CAS NO:139504-50-0 Solubility:DMSO : ≥ 83.33 mg/mL (112.87 mM)
Molecular Formula:C35H48ClN3O10S Package:Package according to customer requirements
Molecular Weight:738.288 Storage:Store at -20℃
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Remarks

Mertansine refers to the thiol-containing maytansinoid, DM1 (N2’-deacetyl-N2’-(3-mercapto-1-oxopropyl)maytansine) attached to a monoclonal antibody through reaction of the thiol group with an SPP (N-succinimidyl 4-(2-pyridyldithio)) linker to create an antibody-drug conjugate or ADC. Experimental ADCs with the SPP-DM1 design include lorvotuzumab mertansine. DM1 can also be linked to an antibody using the SMCC (4-(3-mercapto-2,5-dioxo-1-pyrrolidinylmethyl)-cylohexanecarboxylic acid) linker, in which case the International Nonproprietary Name of the conjugate formed contains the word emtansine. DM1 and its attachment via these linkers result from ImmunoGen Inc research. Trastuzumab emtansine (T-DM1) is an anti-HER2/neu antibody-drug conjugate.

 

 

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