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PHA-767491 CAY10572

PHA-767491 CAY10572 845714-00-3
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Chemical Information
Product name:PHA-767491 CAY10572 Purity:98% min
CAS NO:845714-00-3 Solubility:Soluble in DMSO
Molecular Formula:C12H12ClN3O Package:Package according to customer requirements
Molecular Weight:249.696 Storage:Store at -20℃
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Remarks

PHA-767491, also known as CAY10572, is a potent, ATP-competitive dual cdc7/cdk9 inhibitor (IC50 values are 10 and 34 nM respectively) that prevents initiation of DNA replication. PHA-767491 Suppresses Hepatocarcinoma Synergistically with 5-Fluorouracil. PHA-767491 in combination with 5-FU exhibited much stronger cytotoxicity and induced significant apoptosis manifested by remarkably increased caspase 3 activation and poly(ADP-Ribose) polymerase fragmentation in HCC cells. PHA-767491 directly counteracted the 5-FU-induced phosphorylation of Chk1, a substrate of Cdc7; and decreased the expression of the anti-apoptotic protein myeloid leukemia cell 1, a downstream target of Cdk9.

 

 

 

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