Bosentan

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Chemical Information

Product name：Bosentan	Purity：98% min
CAS NO：147536-97-8	Solubility：DMSO: ≥ 275 mg/mL
Molecular Formula：C₂₇H₂₉N₅O₆S	Package：Package according to customer requirements
Molecular Weight：551.614	Storage：Store at -20℃

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Remarks

Bosentan is a mixed Endothelin Receptor Antagonist which is used as a vasodilator. Bosentan is an inhibitor of ETAR and ETBR. It is used for the treatment of pulmonary artery hypertension (PAH). Bosentan blocks the action of endothelin molecules that would otherwise promote narrowing of the blood vessels and lead to high blood pressure.

Properties:

Appearance & Physical State: Pale Yellow to Off-White Solid

Density: 1.326 g/cm3

Boiling Point: 742.3ºC at 760 mmHg

Melting Point: 195ºC

Flash Point: 402.8ºC

Refractive Index: 1.607

Vapor Pressure: 0mmHg at 25°C

Endothelin Receptor Inhibitors Related Prodcuts:

Bosentan hydrate; Macitentan; Ambrisentan; Sparsentan; Zibotentan

References

[1]. Dhillon S, et al. Bosentan: a review of its use in the management of mildly symptomatic pulmonary arterial hypertension. Am J Cardiovasc Drugs. 2009;9(5):331-50.

[2]. Akamata K, et al. Bosentan reverses the pro-fibrotic phenotype of systemic sclerosis dermal fibroblasts via increasing DNA binding ability of transcription factor Fli1. Arthritis Res Ther. 2014 Apr 3;16(2):R86.