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Zibotentan 186497-07-4
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Chemical Information
Product name:Zibotentan Purity:98% min
CAS NO:186497-07-4 Solubility:10 mM in DMSO
Molecular Formula:C19H16N6O4S Package:Package according to customer requirements
Molecular Weight:424.433 Storage:Store at -20℃
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Zibotentan (ZD4054) is an orally administered, potent and specific ETA-receptor (endothelin A receptor) antagonist (IC50 = 21 nM). IC50 value: 21 nM Target: ETA receptor Zibotentan is capable of inhibiting or reducing the multitude of effects that are evoked by ET-1 activation of the ETA receptor and which promote tumor survival, growth and progression. Zibotentan (ZD4054) treatment produced significant inhibition of tumor growth in ovarian and breast xenografts.
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