Ambrisentan

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Chemical Information

Product name：Ambrisentan	Purity：98% min
CAS NO：177036-94-1	Solubility：DMSO : ≥ 76 mg/mL (200.84 mM)
Molecular Formula：C₂₂H₂₂N₂O₄	Package：Package according to customer requirements
Molecular Weight：378.421	Storage： Store at -20℃

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Remarks

Ambrisentan, also known as BSF-208075 and LU-208075, is a drug indicated for use in the treatment of pulmonary hypertension. Ambrisentan, which relaxes those muscles, is an endothelin receptor antagonist, and is selective for the type A endothelin receptor (ETA). Ambrisentan significantly improved exercise capacity (6-minute walk distance) compared with placebo in two double-blind, multicenter trials (ARIES-1 and ARIES-2). Ambrisentan was approved by the U.S. Food and Drug Administration (FDA) and European Medicines Agency, and designated an orphan drug, for the treatment of pulmonary hypertension.

Properties:

Density: 1.228g/cm3

Boiling Point: 551.1ºC at 760mmHg

Flash Point: 287.1ºC

Refractive Index: 1.593

Vapor Pressure: 5.56E-13mmHg at 25°C

Endothelin Receptor Inhibitors Related Prodcuts:

Bosentan; Bosentan hydrate; Macitentan; Sparsentan; Zibotentan

References

[1]. Okamoto T, et al. Antifibrotic effects of Ambrisentan, an endothelin-A receptor antagonist, in a non-alcoholic steatohepatitis mouse model. World J Hepatol. 2016 Aug 8;8(22):933-41.

[2]. Lisk C, et al. Nrf2 activation: a potential strategy for the prevention of acute mountain sickness. Free Radic Biol Med. 2013 Oct;63:264-73.