UNC0642

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Chemical Information

Product name：UNC0642	Purity：99% min
CAS NO：1481677-78-4	Solubility：DMSO : 295 mg/mL (539.60 mM)
Molecular Formula：C₂₉H₄₄F₂N₆O₂	Package：Package according to customer requirements
Molecular Weight：546.695	Storage：Store at -20℃

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Remarks

UNC0642 is a potent, selective inhibitor of histone methyltransferases G9a/GLP with IC50s less than 2.5 nM for G9a and GLP and shows more than 300-fold selective for G9a and GLP over a broad range of kinases, GPCRs, transporters, and ion channels.

Histone Methyltransferase Inhibitors Related Products:

EPZ005687; GSK343; Tazemetostat; UNC1999; MM-102; SGC0946; SGC2085; OICR-9429; HLCL-61 HCL; GSK591; SGC707; GSK503; EPZ015666; PFI-2 HCl; UNC0638; GSK-126; EPZ004777; GSK3326595; LLY-507; BRD4770 ; Pinometostat

References

[1]. Liu F, et al. Discovery of an in vivo chemical probe of the lysine methyltransferases G9a and GLP. J Med Chem. 2013 Nov 14;56(21):8931-8942.

[2]. Wang L, et al. Targeting EHMT2 reverses EGFR-TKI resistance in NSCLC by epigenetically regulating the PTEN/AKT signaling pathway. Cell Death Dis. 2018 Jan 26;9(2):129