OICR-9429

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Chemical Information

Product name：OICR-9429	Purity：98% min
CAS NO：1801787-56-3	Solubility：DMSO : ≥ 32 mg/mL (57.60 mM)
Molecular Formula：C₂₉H₃₂F₃N₅O₃	Package：Package according to customer requirements.
Molecular Weight：555.6022	Storage：Store at -20℃

Quality control

COA

Remarks

OICR-9429 is a potent and selective chemical probe suitable to help dissect the biological role of WDR5 (Kdisp < 100 nM). OICR-9429 selectively inhibited proliferation and induced differentiation in p30-expressing human AML cells. OICR-9429 disrupts the interaction of Wdr5 with MLL in cells, thereby selectively triggering a differentiation program in p30-expressing leukemia cells.

Histone Methyltransferase Inhibitors Related Products:

EPZ005687; GSK343; Tazemetostat; UNC1999; MM-102; SGC0946; SGC2085; HLCL-61 HCL; GSK591; SGC707; GSK503; EPZ015666; PFI-2 HCl; UNC0642; UNC0638; GSK-126; EPZ004777; GSK3326595; LLY-507; BRD4770 ; Pinometostat

References

[1]. Grebien F et al. Pharmacological targeting of the Wdr5-MLL interaction in C/EBPα N-terminal leukemia. Nat Chem Biol. 2015 Aug;11(8):571-8.

[2]. Getlik M et al. Structure-Based Optimization of a Small Molecule Antagonist of the Interaction Between WD Repeat-Containing Protein 5 (WDR5) and Mixed-Lineage Leukemia 1 (MLL1). J Med Chem. 2016 Mar 24;59(6):2478-96.