Ritonavir

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Chemical Information

Product name：Ritonavir	Purity：99% min
CAS NO：155213-67-5	Solubility：DMSO : 25 mg/mL (34.68 mM)
Molecular Formula：C₃₇H₄₈N₆O₅S₂	Package：Packaging according to customer requirements.
Molecular Weight：720.94	Storage：Store at -20℃

Quality control

COA

Remarks

Ritonavir (ABT-538, A 84538, RTV, Norvir, Norvir Softgel) is a Cytochrome P450 3A and Protease Inhibitor; Also inhibits Cytochrome P450 2D6, P-Glycoprotein and induces Cytochrome P450 2C19, Cytochrome P450 1A2, Cytochrome P450 2C9, Cytochrome P450 2B6 and UDP Glucuronosyltransferases. Ritonavir induces apoptosis.

HIV Protease Inhibitors Related Prodcuts:

Lopinavir; Atazanavir; Panobinostat; Temsavir; Darunavir; Pepstatin A

References

[1]. Eagling VA, et al. Differential inhibition of cytochrome P450 isoforms by the protease inhibitors, ritonavir, saquinavir and indinavir. Br J Clin Pharmacol. 1997 Aug;44(2):190-4.

[2]. Kumar GN, et al. Cytochrome P450-mediated metabolism of the HIV-1 protease inhibitor ritonavir (ABT-538) in human liver microsomes. J Pharmacol Exp Ther. 1996 Apr;277(1):423-31.

[3]. Weichold FF, et al. HIV-1 protease inhibitor ritonavir modulates susceptibility to apoptosis of uninfected T cells. J Hum Virol. 1999 Sep-Oct;2(5):261-9.