JNJ-632

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Chemical Information

Product name：JNJ-632	Purity：98% min
CAS NO：1572510-42-9	Solubility：DMSO : 125 mg/mL (330.32 mM)
Molecular Formula：C₁₈H₁₉FN₂O₄S	Package：Package according to customer requirements.
Molecular Weight：378.4184	Storage：Store at -20℃

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Remarks

JNJ-632 is a potent HVV capsid assembly modulator and HBV replication inhibitor with EC50 of 100-200 nM for genotypes A-D. Administration of JNJ-632 in HBV genotype D infected chimeric mice, resulted in a 2.77 log reduction of the HBV DNA viral load.

JNJ-632 is a capsid assembly modulator inhibiting hepatitis B virus (HBV). JNJ-632 inhibits HBV DNA HepG2.2.15 and HBV DNA HepG2.117 with EC50s of 0.12 and 0.43 uM, respectively. In the high-content multiparameter cytotoxicity (HepG2), JNJ-632 shows EC20s in the 10-30 uM range (considered weakly cytotoxic).

HBV Inhibitors Related Products:

Doxorubicin HCl; Emtricitabine; BAY41-4109 Racemic; OSS-128167

References

[1]. Vandyck K, et al. Synthesis and Evaluation of N-Phenyl-3-sulfamoyl-benzamide Derivatives as Capsid Assembly Modulators Inhibiting Hepatitis B Virus (HBV). J Med Chem. 2018 Jul 26;61(14):6247-6260.