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OSS-128167

OSS-128167 887686-02-4
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Chemical Information
Product name:OSS-128167 Purity:98% min
CAS NO:887686-02-4 Solubility:DMSO : 103.3 mg/mL (281.99 mM)
Molecular Formula:C19H14N2O6 Package:Package according to customer requirements
Molecular Weight:366.329 Storage:Store at -20℃
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Remarks

OSS_128167 is a selective SIRT6 inhibitor with IC50s of 89, 1578 and 751 μM for SIRT6, SIRT1 and SIRT2, respectively. OSS_128167 inhibits SIRT6 in the micromolar range, but shows promising selectivity, since its IC50 value for SIRT6 is approximately 17 times lower compare to the IC50for SIRT1 and 9 times lower compare to SIRT2. OSS_128167 (200 μM) induces chemosensitization in primary multiple myeloma (MM) cells (NCI-H929), as well as in melphalan-resistant (LR-5) and doxorubicin-resistant (Dox40) MM cell lines.

 

 

 

Sirtuin Inhibitors Related Products:

Selisistat; Thiomyristoyl; Tenovin-6; Tenovin-6 HCl; Resveratrol; Tenovin-3; Inauhzin

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