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EX 527 Selisistat

EX 527 Selisistat 49843-98-3
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Chemical Information
Product name:EX 527 Selisistat Purity:98% min
CAS NO:49843-98-3 Solubility:10 mM in DMSO
Molecular Formula:C13H13ClN2O Package:Package according to customer requirements
Molecular Weight:248.708 Storage:Store at -20℃
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Remarks

Selisistat, also known as EX-527, is a SirT1 inhibitor for treatment of Huntington's disease. EX-527 inhibits Sirtuins by exploiting their unique NAD+-dependent deacetylation mechanism. Galectin-9 in Combination With EX-527 Prolongs the Survival of Cardiac Allografts in Mice After Cardiac Transplantation. Ex-527 is widely used as a major inhibitor of Sirtuin enzymes, which are a family of highly conserved protein deacetylases and have been linked with caloric restriction and aging by modulating energy metabolism, genomic stability, and stress resistance.

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