EX 527 Selisistat

Size	Price	Stock	Quantity
Get Quotation Now Add to Cart Bulk Inquiry

Shipping and handling fee USD40, Free delivery is qualified when the total value of your order exceeds USD500.If the item is temporarily out of stock. Please email to order@pharm-intermediates.com,we will inform you when we have it in stock.

Chemical Information

Product name：EX 527 Selisistat	Purity：98% min
CAS NO：49843-98-3	Solubility：DMSO : ≥ 100 mg/mL (402.07 mM)
Molecular Formula：C₁₃H₁₃ClN₂O	Package：Package according to customer requirements
Molecular Weight：248.708	Storage：Store at -20℃

Quality control

Remarks

Selisistat, also known as EX-527, is a SirT1 inhibitor for treatment of Huntington's disease. EX-527 inhibits Sirtuins by exploiting their unique NAD+-dependent deacetylation mechanism. Galectin-9 in Combination With EX-527 Prolongs the Survival of Cardiac Allografts in Mice After Cardiac Transplantation. Ex-527 is widely used as a major inhibitor of Sirtuin enzymes, which are a family of highly conserved protein deacetylases and have been linked with caloric restriction and aging by modulating energy metabolism, genomic stability, and stress resistance.

Sirtuin Inhibitors Related Products:

Thiomyristoyl; Tenovin-6; Tenovin-6 HCl; Resveratrol; Tenovin-3; Inauhzin; OSS-128167

References

[1]. Solomon JM, et al. Inhibition of SIRT1 catalytic activity increases p53 acetylation but does not alter cell survival following DNA damage. Mol Cell Biol. 2006 Jan;26(1):28-38.

[2]. Jia Y, et al. SIRT1 is a regulator in high glucose-induced inflammatory response in RAW264.7 cells. PLoS One. 2015 Mar 20;10(3):e0120849.