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Inauhzin INZ

Inauhzin INZ 309271-94-1
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Chemical Information
Product name:Inauhzin INZ Purity:98% min
CAS NO:309271-94-1 Solubility:DMSO : 21 mg/mL (44.72 mM)
Molecular Formula:C25H19N5OS2 Package:Package according to customer requirements
Molecular Weight:469.581 Storage:Store at -20℃
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Remarks

Inauhzin is a potent SIRT inhibitor, which effectively reactivates p53 by inhibiting SIRT1 activity, promotes p53-dependent apoptosis of human cancer cells without causing apparently genotoxic stress. Moreover, Inauhzin stabilizes p53 by increasing p53 acetylation and preventing MDM2-mediated ubiquitylation of p53 in cells, though not directly in vitro. Remarkably, Inauhzin inhibits cell proliferation, induces senescence and tumour-specific apoptosis, and represses the growth of xenograft tumours derived from p53-harbouring H460 and HCT116 cells without causing apparent toxicity to normal tissues and the tumour-bearing SCID mice.

 

 

 

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Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.
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