Tenovin-3 is able to increase p53 levels, determined in MCF-7 cells treated for 6 hr at 10 μM.
Target: p53
in vitro: Tenovins inhibit the activities of human SirT1 and SirT2, two members of the NAD+-dependent class III histone deacetylases that also belong to the sirtuin family.
Synonyms:
1-(4-amino-phenyl)-3-(4-tert-butyl-benzoyl)-thiourea;
N-[(4-aminophenyl)-carbamothioyl]-4-tert-butyl-benzamide;
Sirtuin Inhibitors Related Products:
Selisistat; Thiomyristoyl; Tenovin-6; Tenovin-6 HCl; Resveratrol; Inauhzin; OSS-128167