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Doxorubicin HCl

Doxorubicin HCl 25316-40-9
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Chemical Information
Product name:Doxorubicin HCl Purity:98% min
CAS NO:25316-40-9 Solubility:DMSO : ≥ 125 mg/mL (215.52 mM)
Molecular Formula:C27H30ClNO11 Package:Package according to customer requirements
Molecular Weight:579.98 Storage:Store at -20℃
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Remarks
Doxorubicin is an anthracycline antibiotic with antineoplastic activity. Doxorubicin, isolated from the bacterium Streptomyces peucetius var. caesius, is the hydroxylated congener of daunorubicin. Doxorubicin intercalates between base pairs in the DNA helix, thereby preventing DNA replication and ultimately inhibiting protein synthesis. Additionally, doxorubicin inhibits topoisomerase II which results in an increased and stabilized cleavable enzyme-DNA linked complex during DNA replication and subsequently prevents the ligation of the nucleotide strand after double-strand breakage. Doxorubicin also forms oxygen free radicals resulting in cytotoxicity secondary to lipid peroxidation of cell membrane lipids; the formation of oxygen free radicals also contributes to the toxicity of the anthracycline antibiotics, namely the cardiac and cutaneous vascular effects.
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