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AT-7519 hcl

AT-7519 hcl 902135-91-5
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Chemical Information
Product name:AT-7519 hcl Purity:98% min
CAS NO:902135-91-5 Solubility:DMSO : ≥ 300 mg/mL (716.49 mM)
Molecular Formula:C17H21Cl2N5O2 Package:Packaging according to customer requirements
Molecular Weight:398.287 Storage:Store at -20℃
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Remarks

AT-7519 is an orally bioavailable small molecule CDK inhibitor with potential antineoplastic activity. AT7519M selectively binds to and inhibits cyclin dependent kinases (CDKs), which may result in cell cycle arrest, induction of apoptosis, and inhibition of tumor cell proliferation. CDKs are serine/theronine kinases involved in regulation of the cell cycle and may be overexpressed in some types of cancer cells.

AT7519 HCl is a multi-CDK inhibitor for CDK1, 2, 4, 6 and 9 with IC50 of 10-210 nM in cell-free assays. It is less potent to CDK3 and little active to CDK7. Phase 2.

 

 

 

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Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.
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